İstanbul Tabip Odası - Klinik Gelişim Dergisi - Astım Özel Sayısı
Cilt 9 / No: 7 - 8 / Temmuz - Ağustos 1996

PREFACE
Günseli Yılmaz

ASTIM EPİDEMİYOLOJİSİ
Bilun Gemicioğlu

ASTIMDA BRONŞ EPİTELİNİN ROLÜ
Ahmet Rasim Küçükusta

ASTIMDA BRONŞ DUVARI ENFLAMASYONU
Nurhayat Yıldırım

ASTIMDA BRONŞ HİPERREAKTİF CEVABI
Nurhayat Yıldırım

NÖRAL MEKANİZMALAR
Bilun Gemicioğlu

ADEZYON MOLEKÜLLERİ
Bilun Gemicioğlu

HAVA KİRLİLİĞİ VE ASTIM
Ahmet Rasim Küçükusta

ASTIM KLİNİĞİ
H. Gül Öngen

ASTIMIN KLİNİK FORMLARI
H. Gül Öngen

ASTIMDA TANI YÖNTEMLERİ
Günay Aydın Tosun

ASTIMDA SOLUNUM FONKSİYON TESTLERİ
Sema Umut

ASTIMDA SİTOLOJİ VE İMMÜNOSİTOLOJİ
Nail Yılmaz

ASTIMDA BRONKODİLATÖR TEDAVİ
Günseli Yılmaz

ASTIMDA ANTİENFLAMATUVAR TEDAVİ
Müzeyyen Erk

AKUT ASTIM ATAĞININ TEDAVİSİ
Mustafa Yaman

ASTIMDA SPESİFİK İMMÜNOTERAPİ
Mustafa Yaman



PREFACE
Günseli Yılmaz

This issue has been designed to draw current attention on a very common and misdiagnosed entity; asthma. There are wide variations in the prevalance of ashma among different countries, but the epidemiologic evidence suggests that most variations are due to environmental factors. In recent years, major advences have been made toward quantifying the risk acsociated with certain enviromental factors, particulary allergen exposure, diet, indoor and outdoor air pollutants, and with genetic factors. It is hoped that this knowledge will be helpful in the design of interventions to reduce the incidence of asthma in the next generation of children. Quite recently, our understanding of basic mechanisms of asthma in the next generation of children. Quite recently, our understanding of basic mechanisms of asthma has increased significantly. Asthma is defined as a chronic disease characterized by ariway inflammatoin, variable airflow obstruction and bronchial hyperresponsiveness. In the past several years, an enormous amount of research has been dedicated to understand the mechanisms operating in asthma. These mechanisms contributing to the increased airway inflammation characteristic of asthma have been discussed in detail in this review.
Over the past decade, the management of asthma has changed substantially with our increased recognition that astham is a chronic inflammatory disease. Recent guidielines emphasize the use of inhaled corticosteroids as firs-line agents in asthmatic patients having more than two exacerbations per week or nocturnal symptoms more than twice per months. Inhaled corticosteroids as firs-line agents in asthmatic patients having more than two exacerbations per week or nocturnal symptoms more than twice per monhth. Inhaled corticosteroids have far fewer adverse effects than their oral counterparts; however, their risk must be carefully considered before use in mild asthma particularly in growing children. Newer and more potent topical anti-inflammatory agents have become avaialbe, yet their mechanism of action, ideal dosage and delivery and adverse effects are still the topic of mush investigations.