Cilt 10 / No: 7 - 8 / Temmuz - Ağustos 1997

PREFACE

VASKÜLİTLER-GİRİŞ VE SINIFLAMA
Hasan Yazıcı

KÜÇÜK DAMAR VASKÜLİTLERİ
İzzet Fresko, Cem Mat, Sabahattin Yurdakul, Nükhet Tüzüner, Yalçın Tüzün

POLİARTİRİTİS NODOZA
Ayhan Dinç, Vedat Hamuryudan

WEGENER GRANÜLOMATOZU
İzzet Fresko, Hasan Yazıcı

DEV HÜCRELİ ARTERİT (TEMPORAL ARTERİT)
Melike Melikoğlu Tanrıverdi, Vedat Hamuryudan, Hasan Yazıcı

TAKAYASU ARTERİTİ
Pınar Kadıoğlu, Vedat Hamuryudan

BEHÇET HASTALIĞI
İzzet Fresko, Vedat Hamuyudan, Sebahattin Yurdakul, Hasan Yazıcı

AİLEVİ AKDENİZ ATEŞİ
Cengiz Korkmaz, Huri Özdoğan

VASKÜLİTLERİ TAKLİT EDEN TABLOLAR (PSÖDOVASKÜLİTLER)
Melike Melikoğlu Tanverdi, Vedat Hamuryudan, Hasan Yazıcı

VASKÜLİTLERDE PATOLOJİ
Ayhan Dinç, Vedat Hamuryudan

VASKÜLİTLERDE LABORATUVAR
Cengiz Korkmaz, Vedat Hamuryudan

VASKÜLİT SENDROMLARINDA RADYOLOJİ
Ayhan Dinç, Cengiz Korkmaz



PREFACE

Vasculitis is a clinicopathological entity that is related to the inflammation of blood vessels and to the complications caused by the hypoperfusion of end-organs and to the systemic manifestations caused by immunological disturbances. It is a major challenge to both rheumatologists and other clinicians since it has a vast symptomatology affecting nearly every organ system in the body with a high degree of overlap between the specific syndromes. There has been a substantial progress in understanding the pathogenetic mechanisms underlying the diseases and in the classification criteria used to categorise them but the unknowns still seem to surpass the discovered.
All the authors of this special issue on vasculitis are members of the Division of Rheumatology of Cerrahpaşa Medical School, a section with a special interest in vasculitis.
An overview of the vasculitic syndromes and the problems encountered in the diagnosis and the classification criteria are reviewed by Prof. Hasan Yazıcı.
The commonly encountered syndrome of the small vessel vasculitides, the extensive etiological factors related to it and the major therapeutic approaches in its management are covered by Dr. İzzet Fresko.
The systemic vasculitides that affect medium sized vessels such as polyarteritis nodosa and the granulomatous forms consisting of Wegener’s granulomatosis and the Churg Strauss syndrome are reviewed by Dr. Ayhan Dinç and Dr. İzzet Fresko with special emphasis to the role of ANCA (anti-neutrophil cytoplasmic antibody) in the diagnosis and in the pathogenesis of the latter diseases.
The large vessel vasculitides that are commonly encountered in the young and elderly such as Takayasu and Temporal arteritis are dealt with in the chapters by Dr. Melike Melikoğlu Tanverdi and Dr. Pınar Kadıoğlu.
The challenging relationship between vasculitis and FMF, a disease that is very prevalent in Turkey, has been analysed by Dr. Cengiz Korkmaz and the latest progress in the pathogenesis and management of Behçet’s syndrome has been reviewed by Dr. İzzet Fresko.
The syndromes mimicking vasculitis, which is an important concept that complicates the differential diagnosis of the already challenging vasculitic syndromes, is written by Dr. Melike Melikoğlu Tanverdi.
Finally, the laboratory aspects and the imaging modalities used in the diagnosis and management of the vasculitides are scrutinised in the papers written by Dr. Cengiz Korkmaz and Dr. Ayhan Dinç.
With this collection of papers on vasculitis, we not only aim to be of some help to the practising physician, but to attract the interest of the students to the fascinating and everchanging field of the vasculitides.
The contributors